Status:
COMPLETED
Cortical Excitability and Decision Making After Total Sleep Deprivation and Sleep Restriction
Lead Sponsor:
Christian Baumann
Conditions:
Acute and Partial Sleep Deprivation
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The investigators examine changes in decision making, vigilance and cortical excitability in healthy male subjects undergoing total acute sleep deprivation (40 hours) on the one hand, and chronic part...
Eligibility Criteria
Inclusion
- Male (in female subjects, menstrual cycle influences sleep)
- Age between 18-35 years
- Right-handedness
- Good general health
- Signed Informed Consent after being informed
Exclusion
- Contraindications on ethical grounds
- Clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc)
- Known or suspected non-compliance, drug or alcohol abuse (\> 5dl wine/ \>1l beer daily)
- Regular medication intake
- Enrolment into a clinical trial within last 4 weeks
- History of seizure or a family history of epilepsy
- Diseases or lesions of the nervous system (acute or residual included neurological and psychiatric diseases)
- History of any moderate or heavy head trauma
- Sleep disorders (e.g. Insomnia, sleep apnea, restless leg syndrome, narcolepsy, etc.)
- Sleep complaints in general or EDS
- Irregular sleep-wake rhythm (e.g. shift working)
- Long (\> 9 hours per night) or short sleepers (\< 7hours per night)
- Sleep efficiency ≤ 80%
- Travelling with time lag less than 1 month ago (or planning to do so within 1 month prior to the study)
- Body Mass Index \< 19 or \> 30 kg/m2
- 5 drinks or food items containing caffeine per day
- 10 cigarettes per day
- Student of one of the following subjects: Mathematics, Physics, Computer Science, Economics, or Psychology (since students of these subjects have profound knowledge of probability calculations, which could interfere with our measurements in decision making)
- The following additional exclusion criteria apply only to subjects with TMS sessions
- History of frequent and/or heavy headache respectively migraine
- History of claustrophobia
- Hearing disorder
- Magnetic Resonance Imaging (MRI) contraindication (such as pacemaker implanted pumps, shrapnel, etc.; full MRI screening form will be filled out - see -Entrance questionnaires)
- No clear TMS evoked potential in the target area during the screening assessment
- These subjects will be invited to participate in the study with no TMS sessions, the other protocol being identical
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT02305225
Start Date
May 1 2013
End Date
January 1 2017
Last Update
November 20 2020
Active Locations (1)
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1
University Hospital Zurich, Division of Neurology
Zurich, Canton of Zurich, Switzerland, 8091