Status:
UNKNOWN
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Lead Sponsor:
Huashan Hospital
Conditions:
Moyamoya Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in frontal areas has been...
Detailed Description
Previous studies of adult moyamoya disease (MMD) have revealed that vascular cognitive impairment (VCI) is the consequence of ischemic damage to dynamic factors such as cerebral hypoperfusion, rather ...
Eligibility Criteria
Inclusion
- Right-handed Chinese people aged over 18 years
- No evidence of recent or remote infarct in the cerebral cortical, basal ganglia, brainstem or cerebellum
- No evidence of recent or remote intracerebral hemorrhage
- Diagnosis confirmed by digital subtraction angiography (DSA) according to Suzuki scale
- No surgical intervention before recruitment
- Physically capable of cognitive testing
- Geographically accessible and reliable for follow-up.
Exclusion
- Significant neurological diseases or psychiatric disorders that could affect cognition
- Other cerebrovascular diseases (such as atherosclerosis or vasculitides) likely to cause focal cerebral ischemia
- Concomitant cerebrovascular diseases (such as aneurysms or arteriovenous malformation) that need surgical intervention
- Severe systemic diseases
- Pregnant or perinatal stage women
- Any diseases likely to death within 2 yeas
- Taking drugs such as benzodiazepine clonazepam
- Any contraindications or allergy to aspirin
- Allergy to iodine or radiographic contrast media
- Past history of surgical revascularization
- Concurrent participation in any other experimental treatment trial
- Any condition that in the surgeon's judgment suggests the patient an unsuitable surgical candidate.
Key Trial Info
Start Date :
March 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2018
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02305407
Start Date
March 1 2016
End Date
May 1 2018
Last Update
August 22 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Neurosurgery, Huashan Hospital
Shanghai, Shanghai Municipality, China, 200040