Status:
UNKNOWN
Effect of Cabergoline on Endometrial Vascularity During IntraCytoplasmic Sperm Injection
Lead Sponsor:
Kasr El Aini Hospital
Conditions:
Infertility
Eligibility:
FEMALE
18-40 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to determine the effect of giving cabergoline to patients at risk of OHSS (ovarian hyperstimulation syndrome) after ovum pick up, on endometrial vascularity and it's effec...
Detailed Description
Following ethical approval of the committee of obstetrics \& gynecology IVF department of kasr al-Aini hospital Cairo University, 150 women attending the IVF unit of Kasr el Aini hospital for manageme...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age ≥18 - ≤40 years
- Normal serum prolactin level.
- Tubal factor of infertility.
- Unexplained infertility.
- BMI ≥ 30 kg/m2.
- Estradiol (E2)\>3,500 pg/ml on day of ovulation trigger.
- Patients who underwent coasting for OHSS prevention.
- More than 20 follicles ≥11 mm on the day of final oocyte maturation.
- Exclusion criteria:
- Contraindication of pregnancy e.g.: Somatic and mental diseases, which are contraindications for carrying of a pregnancy and childbirth, inborn malformations or acquired deformations of uterus cavity which make embryo implantation or carrying of a pregnancy impossible ,ovarian tumors.
- Severe Male factor infertility.
- Hyperprolactinemic patients.
- Frozen embryo transfer cycles
- Uterine Anomalies.
- Uterine synechia.
- History of Genital Tuberculosis.
- Repeated implantation failure in ICSI.
- On medication that is known to alter prolactin levels e.g antipsychotics, Atypical agents and risperidone
- Thyroid dysfunction.
- Medical disorders affecting serum prolactin eg acromegaly ,chronic renal failure and hypothyroidism
Exclusion
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT02306564
Start Date
December 1 2014
End Date
December 1 2017
Last Update
December 6 2016
Active Locations (1)
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1
Assissted reproduction unit Kasr alaini hospital
Ḩadā’iq al Qubbah, Cairo Governorate, Egypt, 11562