Status:
ACTIVE_NOT_RECRUITING
Sickle Cell Hemoglobinopathies and Bone Health
Lead Sponsor:
UConn Health
Conditions:
Sickle Cell Disease
Sickle Cell Trait
Eligibility:
FEMALE
18-45 years
Brief Summary
This research study has two purposes. The first purpose is to determine whether having sickle cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than expected. Ne...
Detailed Description
SCD is a hereditary disease arising only when two parents carrying sickle cell trait (SCT) conceive a child. SCT is clinically silent but very common in African Americans with a \~10% prevalence, alth...
Eligibility Criteria
Inclusion
- Age 18-45 years.
- Female.
- Regular menstrual periods.
- Self-identification of African American race.
Exclusion
- Taking oral contraceptives or medications known to influence bone metabolism (e.g. Glucocorticoids, anti-resorptive or anabolic medications for osteoporosis, pharmacologic Vit D dosing).
- Known metabolic bone disorder (e.g. uncontrolled thyroid disease, hyperparathyroidism).
- Pregnant, breast-feeding, or within 3 months post-partum.
- Taking an investigational drug.
Key Trial Info
Start Date :
May 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT02306993
Start Date
May 1 2014
End Date
December 1 2025
Last Update
March 27 2025
Active Locations (1)
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1
UConn Health
Farmington, Connecticut, United States, 06030