Status:
COMPLETED
Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI
Lead Sponsor:
James J. Peters Veterans Affairs Medical Center
Conditions:
Hypotension, Postural
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
Due to de-centralized cardiovascular control, persons with spinal cord injury (SCI) experience blood pressure (BP) dysregulation which manifests in chronic hypotension with exacerbation during orthost...
Detailed Description
Due to de-centralized cardiovascular control, persons with spinal cord injury (SCI) experience blood pressure (BP) dysregulation which manifests in chronic hypotension with exacerbation during orthost...
Eligibility Criteria
Inclusion
- Age 18-65 years old
- Spinal cord injury with American Spinal Injury Association Impairment Scale (AIS) level of Grade A, B, C or D 9non-ambulatory)
- Neurological level of injury C3-T2
- Duration of injury greater than 1 year
Exclusion
- Currently taking medications with known blood pressure raising or lowering effects.
- Taking over-the-counter medications for allergies or cold symptoms 24-hours prior to testing.
- I have a C3 level of injury and I am ventilator dependent.
- History of cardiovascular arrhythmias (especially slow heart rate, less than 45 bpm), block in the electrical signal within the heart, cardiac arrest.
- History of convulsions or seizures.
- Currently taking medication to treat active asthma.
- Thyroid problems.
- Current smoker.
- Known coronary heart and/or artery disease.
- High blood pressure
- Diabetes
- Current illness or infection
- Major surgery in the last 30 days
- Hypersensitivity to pyridostigmine, bromides, or any component of the formulation; (as determined by review of known drug allergies reported in the medical history intake form and confirmed by the study physician)
- Pregnancy
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02307526
Start Date
January 1 2011
End Date
March 1 2015
Last Update
July 21 2017
Active Locations (1)
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1
Kessler Institute for Rehabilitation
West Orange, New Jersey, United States, 07052