Status:
COMPLETED
Investigation of Serotonin Receptor Binding in the Migraine Brain Using Positron Emission Tomography
Lead Sponsor:
Danish Headache Center
Conditions:
Migraine Without Aura
Eligibility:
All Genders
18-65 years
Brief Summary
Migraine affects 16% of the world population and is one of the most disabling of all disorders. It is a complex brain disorder characterized primarily by recurrent headache attacks. The signaling mole...
Eligibility Criteria
Inclusion
- Inclusion Criteria, both groups:
- • Written informed consent
- Inclusion Criteria, episodic migraine patients:
- Migraine without aura according to the International Headache Society (IHS) 0-4 days per month
- The migraine is treatable with sumatriptan
- Inclusion Criteria, chronic migraine patients: Fulfill IHS criteria for chronic migraine
- Inclusion Criteria, healthy controls:
- Do not suffer from migraine according to IHS
- Do not have any first degree relatives with migraine
- Exclusion Criteria:
- Tension type headache more than 5 days per month during the last year.
- Tension type headache on the experimental day.
- Any other primary headache disorder
- Migraine 48 hour before and after the experimental day (only episodic migraine patients)
- Use of antimigraine medication or pain-killer on the experimental day before PET
- Pregnant or breastfeeding women.
- Contraindications against MRI.
- History or clinical sign of cardio- or cerebrovascular disease.
- Untreated severe mental disorder or drug abuse.
- Other diseases or disorders interpreted, by the examining doctor, to interfere with participation in the study.
- Not accepting information about potential accidental findings during the experiment.
Exclusion
Key Trial Info
Start Date :
January 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT02309606
Start Date
January 1 2015
End Date
December 1 2017
Last Update
January 31 2018
Active Locations (1)
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1
Danish Headache Center, Glostrup Hospital
Glostrup, Copenhagen, Denmark, 2600