Status:
UNKNOWN
Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis
Lead Sponsor:
University College Dublin
Collaborating Sponsors:
Health Research Board, Ireland
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
50+ years
Brief Summary
Pain is the dominant symptom of knee osteoarthritis and recent evidence suggests factors outside of local joint pathology, such as pain sensitization, can contribute significantly to the pain experien...
Detailed Description
BACKGROUND The pathophysiology of knee OA pain is complex. Altered processing of nociceptive inputs at spinal and higher brain centers may help explain discrepancies between pain severity and patholo...
Eligibility Criteria
Inclusion
- Knee osteoarthritis diagnosed by American College of Rheumatology clinical criteria
- Knee pain must be the primary musculoskeletal complaint participant is seeking treatment for
- Pain duration greater than 3 months
- Pain severity ≥ 5/10 on Numerical Rating Scale
- Willing to abstain from simple analgesics and NSAIDs for 24 hours prior to testing
- Willing and able to give full consent
Exclusion
- Lumbar or cervical radiculopathy,
- Systematic inflammatory disease,
- Positive screen for diabetic neuropathy
- Past medical history
- Previous surgery or disease of the peripheral or central nervous system,
- Sensory loss secondary to chemotherapy or radiotherapy
- Fibromyalgia
- Chronic fatigue syndrome
- Cognitive or psychiatric disorder interfering with ability to cooperate with assessment
- Injection or physiotherapy treatment for knee joint within previous 3 months
- Taking anti-depressant or anti-convulsant medication
Key Trial Info
Start Date :
June 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2016
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT02310945
Start Date
June 1 2014
End Date
January 1 2016
Last Update
December 8 2014
Active Locations (3)
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1
St. James's Hospital
Dublin, Dublin, Ireland, 2
2
St. Vincent's University Hospital
Dublin, Dublin, Ireland, 4
3
Tallaght Hospital
Dublin, Dublin, Ireland