Status:
COMPLETED
Genes Involved in Lipid Disorders
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Lipid Disorders
Eligibility:
All Genders
2-99 years
Brief Summary
Background: \- Genes are the instructions our body uses to function. Researchers can look for changes, or variants, in the genes. The goal of this study is to find new gene changes that lead to lipid...
Detailed Description
The primary purpose of this discovery protocol is to identify new lipid genes from subjects with rare genetic lipids disorders. We will take advantage of the new technology of whole exome sequencing t...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Index cases to be included are those with unusual dyslipidemia. Relatives of affected individuals may also be included as appropriate.
- Child Index: greater than or equal to 2 years older
- Adult Index: greater than or equal to18 years older
- Child relatives (siblings, cousins): greater than or equal to 2 years older
- Adult Relative: greater than or equal to18 years older
- (Biological parent, aunt, uncle or grandparent)
- EXCLUSION CRITERIA:
- Inability or unwillingness to provide informed consent or assent
- Prisoners or other institutionalized persons will not be allowed to participate.
- Children \<2 years of age.
Exclusion
Key Trial Info
Start Date :
November 26 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 2 2021
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT02311335
Start Date
November 26 2014
End Date
September 2 2021
Last Update
January 5 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892