Status:
COMPLETED
rTMS for Executive Function Deficits in Autism Spectrum Disorder
Lead Sponsor:
Centre for Addiction and Mental Health
Collaborating Sponsors:
Academic Health Science Centres
Conditions:
Autism Spectrum Disorder
Eligibility:
All Genders
16-35 years
Phase:
NA
Brief Summary
In this study, the investigators will be examining the effects of repetitive transcranial magnetic stimulation (rTMS) on executive function deficits in individuals with autism spectrum disorder. Half ...
Detailed Description
This study is a randomized, double blind, sham controlled study to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) as a treatment for executive function deficits in indivi...
Eligibility Criteria
Inclusion
- Inclusion Criteria Autism Spectrum Disorder (ASD):
- Are fluent in the English language
- Have a diagnosis of high functioning ASD (HF-ASD) (i.e., are verbal with an Intelligence Quotient (IQ) ≥ 70)
- Are competent to consent based on the subjects' ability to provide a spontaneous narrative description of the key elements of the study
- Are clinically stable as determined by their treating physician, with no medication changes over the past 4 weeks
- Exclusion Criteria (ASD):
- Have a history of substance abuse or dependence in the last 6 months or have a positive urine toxicology screen
- Have a concomitant major medical or neurologic illness
- Have had a seizure in the past, or have a first-degree relative with epilepsy
- Have an abnormal clinical EEG
- Are pregnant or likely to get pregnant during the next 4 weeks
- Are clinically unstable
- Are on benzodiazepines or anticonvulsant medication
- Have a history of rTMS treatment.
- Inclusion Criteria (Healthy Controls):
- Are fluent in the English language
- Competent to consent
- Exclusion Criteria (Healthy Controls):
- Have a history of substance abuse or dependence in the last 6 months or have a positive urine toxicology screen
- Have a major medical or neurologic illness
- Have a diagnosed learning disorder or impaired academic or adaptive functioning on history
- Are pregnant
- Have an IQ \< 80
- Have a psychiatric diagnosis on diagnostic interview assessments.
Exclusion
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 4 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT02311751
Start Date
October 1 2014
End Date
May 4 2018
Last Update
March 6 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Centre for Addictions and Mental Health
Toronto, Ontario, Canada, M6J 1H4