Status:
COMPLETED
Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients
Lead Sponsor:
Domonkos Trásy
Conditions:
Bacterial Infection
Eligibility:
All Genders
18+ years
Brief Summary
The value of procalcitonin change from the day before to the day when infection was suspected in predicting bacterial infection in intensive care patients.
Detailed Description
Starting antibiotic therapy early in critically ill patients with suspected infection is of utmost importance with significant effect on survival. Procalcitonin is a reliable sepsis marker but results...
Eligibility Criteria
Inclusion
- Clinical signs of infection
- Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
- Microbiological sample sent for staining
- Inflammatory markers available from the previous day
Exclusion
- Patients younger than 18 years
- Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
- Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
- Following cardiopulmonary resuscitation
- End stage diseases with a "do not resuscitate" order
- Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
- Post cardiac surgery patients
Key Trial Info
Start Date :
October 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT02311816
Start Date
October 1 2012
End Date
October 1 2013
Last Update
December 8 2014
Active Locations (1)
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1
Department of Anaesthesiology and Intensive Therapy
Szeged, Csongrád megye, Hungary, H-6725