Inclusion Criteria:

• Age ≥ 70 years
• Patient considered able to receive chemotherapy
• Lee score detailed faxed to CRGA
• Stage III colon adenocarcinoma
• R0 resection of the primary tumor
• Start of the potential adjuvant chemotherapy within 12 weeks after surgery
• No prior chemotherapy for colon cancer
• Geriatric Self-administered questionnaire completed faxed to CRGA
• Geriatric Questionnaire completed by the team faxed to CRGA
• Effective contraception for men patients throughout treatment and for at least 6 months after discontinuation of oxaliplatin
• Consent signed

Exclusion Criteria:

• Other progressive disease (cancer uncontrolled for less than 2 years)
• Rectal Cancer (located less than 15 cm from the anal verge endoscopy or sub-peritoneal)
• ANC <2000 / mm3 for group 1 and ANC <1500 / mm3 for group 2 and platelets <100,000 / mm3 or hemoglobin <9 g / dL
• Neuropathy for patients in group 1
• Known deficit of dihydropyrimidine dehydrogenase (DPD)
• Patients with severe hepatic insufficiency
• Any contrindication to the drugs used in the study
• Inability to submit to medical follow-up for geographical, social or psychological reasons.