Inclusion Criteria for Part A and Part B:

• Written informed consent and assent, if applicable

Inclusion Criteria for Part A (Cross Sectional Study of PAP Syndrome)

• History of chest computed tomogram or chest radiograph findings compatible with PAP

• History of diagnosis of PAP made by at least one of the following methods:

  • Positive (Abnormal) serum GMAb test -OR-
  • Lung biopsy clearly documenting the presence of PAP of any type or degree -OR-
  • Bronchoalveolar lavage cytology compatible with PAP -OR-
  • Recessive or compound mutations in genes known to cause PAP, i.e. GM-CSF receptor α or β chain, GM-CSF, surfactant protein B or C or ABCA3, ABCG1, ABCA1, TTF1

Inclusion Criteria For Part B (Longitudinal & PRO Survey Study of autoimmune PAP Patients)

• Diagnosis of autoimmune PAP as indicated by:

  • Positive (Abnormal) Serum GMAb Test -AND-
  • History of chest CT or x-rays findings compatible with PAP -OR-
  • Lung biopsy clearly documenting the presence of PAP of any type or degree -OR-
  • Bronchoalveolar lavage cytology compatible with PAP

Exclusion Criteria or Part A and Part B:

• Individuals who have a serious medical illness that, in the opinion of the investigator, is likely to interfere with completion of the study will be excluded.

For Part A (Cross-sectional Study of PAP Syndrome)

• Individuals that do not have a diagnosis of PAP

For Part B (Longitudinal & PRO Survey Study of autoimmune PAP Patients)

• Individuals that do not have a diagnosis of autoimmune PAP