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Status:

COMPLETED

I-CAN Biocollection

Lead Sponsor:

Nantes University Hospital

Collaborating Sponsors:

Institut National de la Santé Et de la Recherche Médicale, France

Conditions:

Intracranial Aneurysm

Eligibility:

All Genders

20+ years

Brief Summary

Intracranial aneurysm (IA) is an asymptomatic cerebrovascular abnormality affecting 3.2% of the general population. The devastating complication of IA is its rupture, resulting in subarachnoid haemorr...

Eligibility Criteria

Inclusion

  • Inclusion criteria indexes and related cases (familial) of intracranial aneurysms:
  • Index: Any patient consulting for a major IA and some typical bifurcation with at least one other case reached akin IA 1st degree
  • Related: All similar to the first degree, aged 20 or more, patients with a family background of IA and some typical bifurcation (≥2 achieved) For the latter, directed by screening with Magnetic resonance imaging (MRI) sequence Time of Flight (TOF), axial T2, EGT2.
  • biocollection of Written Consent for participation in the collection of biological samples
  • Inclusion criteria sporadic cases of IA:
  • Any patient consulting for IA and some typical bifurcation
  • Patients aged 20 years or older
  • biocollection of Written Consent for participation in the collection of biological samples
  • Non Inclusion Criteria:
  • Patients who have shown the inability or refusal to sign the consent informed biocollection
  • syndromic diagnosis known as AIC provider
  • Marfan Syndrome
  • AOS with SMAD 3
  • Danlos Syndrome Elhers type II and IV
  • Autosomal Dominant Polycystic
  • Moyamoya Syndrome
  • character of IA:
  • Dissecting or fusiform
  • Combined with an arteriovenous malformation
  • Blister-like
  • mycotic
  • Pathology of the cerebral white matter detected on MRI suggestive:
  • Mutation COL4A1

Exclusion

    Key Trial Info

    Start Date :

    March 3 2016

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ACTUAL

    End Date :

    December 31 2020

    Estimated Enrollment :

    3078 Patients enrolled

    Trial Details

    Trial ID

    NCT02712892

    Start Date

    March 3 2016

    End Date

    December 31 2020

    Last Update

    September 9 2021

    Active Locations (20)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 5 (20 locations)

    1

    Angers University Hospital

    Angers, France, 49933

    2

    Besançon University Hospital

    Besançon, France, 25030

    3

    Bordeaux University Hospital

    Bordeaux, France, 33404

    4

    Henri Mondor Hospital (AP-HP)

    Créteil, France, 94000