Status:
TERMINATED
Exercise in Multiple Sclerosis
Lead Sponsor:
University of Minnesota
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Exercise therapy in MS patients has proven benefits on mobility, mood, motor function and quality of life. While the beneficial effects of exercise on cardiovascular and musculoskeletal function are w...
Detailed Description
Multiple Sclerosis (MS) is a chronic, disabling neurologic disease characterized by damage to myelin and axons in the central nervous system (CNS). Current therapy for MS primarily consists of immunom...
Eligibility Criteria
Inclusion
- Male or female patients with a confirmed diagnosis of MS by revised McDonald criteria
- Age ≥ 18 years
- Expanded Disability Status Scale (EDSS) 0-6.0, inclusive.
- Able to understand the consent process, and the use of the wristband activity tracker.
- Sedentary by self-report (answers no to the question: "Do you exercise regularly?"
- Willing to make sincere effort to comply with the study objective of increasing their physical activity as much as possible (with goal of at least 100% increase) and to maintain that increased activity level for six months (if randomized to the exercise group).
Exclusion
- Current serious medical condition which would likely limit subject's ability to achieve sustained increase in physical activity, or put them at risk for doing so in the investigators' opinion (e.g. significant cardiovascular or respiratory disease, cancer, cancer, orthopedic disease, etc)
- Subjects that have a central nervous system disorder (in addition to MS) that is not considered secondary to MS
- Subjects that have implanted metal, pacemaker, etc. that may interfere with the MEG/MRI scan or who are otherwise unable to complete the MEG/MRI scan procedure without sedation (e.g. due to claustrophobia, obesity)
- weight \> 300 pounds
Key Trial Info
Start Date :
January 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 13 2020
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT02716701
Start Date
January 1 2016
End Date
August 13 2020
Last Update
August 25 2020
Active Locations (1)
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1
VA Medical Center
Minneapolis, Minnesota, United States, 55417