Status:
COMPLETED
Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Dystonia
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Dystonia is defined as a syndrome of sustained muscle contractions resulting in repetitive movements and abnormal postures. DYT1 is the most common form of genetic dystonia, but the link between genom...
Detailed Description
The purpose of this study is to demonstrate that the phenotype of dystonia is associated with the degree of striatal ACh-I alterations. In this molecular imaging study, the investigators will directl...
Eligibility Criteria
Inclusion
- Man or woman 18 to 75 years, with health insurance European health insurance card (for resident patients in EU), insurance by bilateral social security agreement signed between his country and France (for resident patients outside the EU)
- Diagnosis of dystonia DYT1 confirmed by molecular biology (TORSINE- A gene mutation)
- Patient who stopped his anticholinergic treatment 48 hours before imaging
Exclusion
- Patients who underwent surgery for deep brain stimulation or under cholinergic treatment.
- Presence of a counter-indication for MRI
- Presence of a counter-indication for TEP Scan with \[18F\]-FEOBV
- Woman premenopausal without effective ongoing contraception (intrauterine device or combined hormonal)
- Patient who underwent a PET examination in the previous month
- Presence of any health problem preventing travel to the imaging service of the University Hospital
- Being under the legal guardianship of another person or being unable to provide consent to participate
- Pregnant or breastfeeding woman
Key Trial Info
Start Date :
January 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT02727361
Start Date
January 1 2016
End Date
March 1 2018
Last Update
February 25 2019
Active Locations (1)
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1
CHU de Bordeaux
Bordeaux, France, 33076