Status:
COMPLETED
Persistence of Zika Virus in Semen After Acute Infection
Lead Sponsor:
Institute of Tropical Medicine, Belgium
Conditions:
Zika Virus
Zika Virus Disease
Eligibility:
MALE
18-80 years
Brief Summary
This is a prospective observational laboratory evaluation of the persistence rate of zika virus (ZIKV) infection in semen by real-time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), and ass...
Detailed Description
Objectives 1. To assess the duration of persistence of zika virus (ZIKV) in semen samples by means of RT-PCR, after acute ZIKV infection. 2. To assess replication fitness of ZIKV in semen, by isolati...
Eligibility Criteria
Inclusion
- Male sex
- Age 18 years or older
- Confirmed ZIKV case, defined as:
- Having traveled to an affected area and developing at least 2 of the following Zika virus disease compatible symptoms within 2 weeks of travel: fever defined as T≥ 37.8°C (axillary measurement), maculopapular rash, arthralgia or non-purulent conjunctivitis.
- Zika virus diagnosis by:RNA detection by RT-PCR in serum or urine during the first 10 days after infection, OR Four-fold or greater change in virus-specific quantitative antibody titers in paired sera, OR Virus-specific Immunoglobulin M (IgM) antibodies in serum with confirmatory virus-specific neutralizing antibodies in the same or a later specimen
Exclusion
- History of, or ongoing urologic malignancy or urologic surgical treatment (including vasectomy).
- Recent (\< 2 years) history of, or ongoing urinary tract infection (including prostatitis, epididymitis, sexually transmitted diseases).
Key Trial Info
Start Date :
February 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT02733796
Start Date
February 1 2016
End Date
September 1 2017
Last Update
March 2 2021
Active Locations (1)
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1
ITM
Antwerp, Belgium, 2000