Status:
COMPLETED
Accuracy of 1.5 T Versus 3 T Magnetic Resonance Arterial Spin Labeling to Measure Renal Blood Flow
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Conditions:
Hypertension
Chronic Kidney Disease
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
In this study we want to compare the accuracy of two methods to measure renal perfusion by MRI spin labelling technique: the first measurement done with the 1.5 T MRI versus the second one obtained wi...
Detailed Description
Magnetic resonance imaging based arterial spin labeling is a technique to measure renal blood flow. Renal perfusion measurement is an important tool to analyze renal function and to detect acute kidne...
Eligibility Criteria
Inclusion
- Male and Female patients are eligible. Females of child bearing potential (WOCBP) are only eligible if pregnancy test at the screening visit is negative and they use adequate contraceptive precautions during the trial.
- Healthy volunteers and patients who have hypertension stage 1 or 2 or patients who have diabetes at a max of 2 oral antidiabetic agents will be included
Exclusion
- eGFR ≤ 45 ml/min/1.75m²
- any cardiovascular or cerebrovascular other other severe events within the last 3 months
- arterial hypertension grad \> 2 ( blood pressure ≥ 180/110)
- Subject who do not give written consent, that pseudonymous data will be transferred in line with the duty of documentation and the duty of notification according to § 12 and § 13 GCP-V
- Any contraindications to MRI
- Brain aneurysm clip
- Implanted cardiac pacemaker, pacemaker wires or defibrillator
- Prosthetic heart valves
- Cochlear implant
- Ocular foreign body
- Implanted insulin pump,
- Tattoo (as determined by imager)
- agoraphobia
Key Trial Info
Start Date :
May 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2019
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02746549
Start Date
May 1 2014
End Date
March 1 2019
Last Update
March 26 2020
Active Locations (1)
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1
Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg
Erlangen, Germany, 91054