Status:
COMPLETED
Eccentric Motor Control After SCI
Lead Sponsor:
Ohio State University
Collaborating Sponsors:
University of Notre Dame
Conditions:
Spinal Cord Injury
Eligibility:
All Genders
18-90 years
Brief Summary
This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill train...
Detailed Description
Lower extremity eccentric motor control is is critically important for locomotor function but is impaired after spinal cord injury (SCI). Even after treadmill training, preliminary evidence indicates ...
Eligibility Criteria
Inclusion
- Individuals with SCI:
- medically approved
- discharged from outpatient rehabilitation for 6 months
- incomplete SCI based on ASIA impairment score (AIS C or D) at neurologic level C1-T10
- ability to take some steps overground and on the treadmill
- 18-90 years old.
- ability to speak English. Note: the quality of life measures have not been validated yet in non-English speaking populations.
Exclusion
- evidence of lower motor neuron injury in the legs
- use of botox in the past 3 months
- pre-existing or confounding neurologic conditions (i.e. brain injury, stroke, HIV)
- acute deep vein thrombosis
- skin wounds in regions where harness or hands provide support
- pregnancy. Note: Persons who are pregnant will not be enrolled as exercise tolerance is unknown in these women with SCI.
- cognitive conditions that preclude providing informed consent
- ventilator-dependence as study results will be confounded by mobility limitations imposed by equipment
- persistent orthostatic hypotension (drop of BP \>30mmHg in treadmill and harness equipment)
- hospitalization for myocardial infarction, cardiac surgery or congestive heart failure exacerbation within 3 months of enrollment in study
- participation in any other concurrent exercise programs.
- Note: Use of anti-spasticity and other medications (dose, frequency) will be monitored throughout training and used as a confounding variable in the analyses.
Key Trial Info
Start Date :
June 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2019
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT02821845
Start Date
June 1 2015
End Date
October 1 2019
Last Update
March 22 2021
Active Locations (1)
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1
The Ohio State University
Columbus, Ohio, United States, 43210