Status:
UNKNOWN
The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Stroke
Lead Sponsor:
Christina Kruuse
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This randomized controlled trial investigates the effect of a single dose of glucagon-like peptide-1 (GLP-1) receptor agonist in the subacute phase of stroke in humans. The primary endpoint is the mea...
Detailed Description
Glucagon-like peptide 1 (GLP-1) receptor agonists are widely used in the treatment of type 2 diabetes because of their ability to mimic the incretin hormone, GLP-1. GLP-1 increases glucose-dependent i...
Eligibility Criteria
Inclusion
- Patients ≥ 18 years with newly symptoms of stroke
- Able to receive exenatide/placebo within 21 days after onset of symptoms
- Radiological confirmed diagnoses of ischemic stroke
- NIHSS between 1-20 at the onset of symptoms
- modified rankin scale (mRS) ≤ 2 prior to onset of symptoms
- Has given written informed consent
Exclusion
- Intracerebral haemorrhage
- Subdural / epidural hemorrhage
- Subarachnoid haemorrhage
- Previously major structural damage to the brain
- Diabetes type 1
- Diabetes type 2
- Known atrial fibrillation
- \> 50% stenosis of internal carotid
- Known allergy to GLP-1 receptor agonists
- Hepatic impairment (ALT\> 3 x upper normal limit)
- Renal impairment (eGFR \<30 ml / min)
- Inflammatory bowel disease
- Previous pancreatitis
- Heart failure (NYHA class 3-4)
- Pregnancy or lactation
- Patient unable to co-operate to the investigation procedures
- Visualization of the middle cerebral artery bilaterally by transcranial dopple not possible
Key Trial Info
Start Date :
August 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT02829502
Start Date
August 1 2016
End Date
November 1 2023
Last Update
March 3 2023
Active Locations (1)
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1
Department of Neurology, Herlev-Gentofte Hospital
Herlev, Denmark, 2730