Status:
UNKNOWN
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Acute Respiratory Failure With Hypercapnia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasiv...
Detailed Description
Humidified high flow nasal oxygen therapy decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the set FiO2 throughout the whole inspiratory phase...
Eligibility Criteria
Inclusion
- Hypoxemic and no hypercapnic acute respiratory failure :
- severe dyspnea at rest with a respiratory rate \>25 breaths/min
- PaO2/FiO2 \<300
- PaCO2 \<45 mmHg,
Exclusion
- age \<18 years
- NPPV contraindications
- past history of respiratory chronic disease (COPD, cystic fibrosis…)
- cardiac pulmonary edema
- Pre-defined intubation
- other than respiratory organ failure : systolic pressure \<90 mmHg,current treatment with epinephrine or norepinephrine, decreased level of consciousness ( Glasgow score ≤ 12)
- profound aplasia (white cells count \<1000/mm 3)
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03229460
Start Date
August 1 2019
End Date
December 1 2019
Last Update
December 5 2018
Active Locations (1)
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1
Ethics Committee of Xinhua Hospital
Shanghai, Shanghai Municipality, China, 200092