Status:
UNKNOWN
the Effect of Tracleer on Tourniquet-associated Hypertension
Lead Sponsor:
Xuzhou Medical University
Conditions:
Tourniquets
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Tourniquet is widely used in orthopedic surgery. However, prolonged tourniquet inflation may cause a gradual rise in blood pressure, which named as tourniquet-associated hypertension. Thus, to effecti...
Detailed Description
At present study, the investigators will use endothelin receptor antagonist, Tracleer (Bosentan), to investigate the effect of Tracleer on tourniquet-associated hypertension during unilateral total kn...
Eligibility Criteria
Inclusion
- Patients underwent selected total knee arthroplasty under general anesthesia
- ASA II-III
- 18\~65 years old
- Signed informed consent voluntarily
Exclusion
- Do not apply tourniquet during the surgery
- Patients underwent emergency surgery
- Having applied tourniquet in last three months
- Patients underwent bilateral total knee arthroplasty
- Dysfunction of liver or kidney
- Anemia (Hb \<90 g/L)
- Serious myocardial disease (eg. coronary heart disease, heart failure, severe arrhythmia)
- Coagulation disorder
- Diabetic
- Leukocyte higher than normal value
- Pneumonia, asthma, chronic obstructive pulmonary disease
- Hypotension before surgery (systolic pressure \< 90 mmHg)
- Pregnant woman or puerpera
- Having being enrolled in other clinical trial in last 3 months
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2018
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03229694
Start Date
August 1 2017
End Date
May 1 2018
Last Update
July 25 2017
Active Locations (1)
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1
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China