Status:
COMPLETED
Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia
Lead Sponsor:
Assiut University
Conditions:
Immune Thrombocytopenia
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Hydroxychloroquine has been reported to have a clinically significant effect on the platelet count in systemic lupus thrombocytopenia. Its action may be due to its immune modulator effect. Immune thro...
Detailed Description
This study will include patients with chronic ITP attending the out patients clinic of Clinical Hematology Unit of Internal Medicine Department of Assiut university Hospital to evaluate the safety and...
Eligibility Criteria
Inclusion
- We will recruit patients with primary chronic ITP patients with ITP lasting for more than 12 months which is proved to be refractory to the standard first line treatment or need to treatment(s) (including, but not limited to, low dose of corticosteroids) to minimize the risk of clinically significant bleeding.
- Subject or their guardian has signed and dated a written informed consent.
- Subject experienced no toxicity or known contraindication to any line of treatments.
Exclusion
- pregnancy.
- liver and kidney function impairment.
- hepatitis c virus(HCV), human immunodeficiency virus (HIV), hepatitis B virus infection.
- patients with systemic lupus erythematosus and/or antiphospholipid syndrome
- lymphoproliferative disorders.
- an active malignancy
- an arterial or venous thrombosis
- Grade III-IV cardiovascular disease .
- Recent history of alcohol/drug abuse.
- Subjects recently treated with drugs that affect platelet function (including but not limited to aspirin, clopidogrel and/or NSAIDs) or anti-coagulants for \> 3 consecutive days within 2 weeks of the study start and until the end of the study.
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03229746
Start Date
August 1 2017
End Date
June 1 2018
Last Update
June 28 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Assiut university hospital
Asyut, Egypt