Status:
UNKNOWN
Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis
Lead Sponsor:
L.V. Prasad Eye Institute
Conditions:
Infection, Fungal
Eligibility:
All Genders
18-90 years
Phase:
PHASE2
PHASE3
Brief Summary
OBJECTIVE To evaluate the efficacy and safety of the concurrent treatment of 5% Natamycin and 1% Voriconazole in patients affected by fungal keratitis METHODS AND MATERIALS STUDY POPULATION Patients w...
Detailed Description
PROTOCOL FOR SUBMISSION AND APPROVAL OF RESEARCH PROJECT TITLE: Combination treatment of 5% Natamycin and 1% Voriconazole in fungal keratitis: a Prospective Randomized double masked clinical trial S...
Eligibility Criteria
Inclusion
- Subjects \> 18 yrs of age Willing to give appropriate informed consent Presence of corneal ulcer measuring \> 2mm in vertical and horizontal dimensions at presentation (epithelial defect and signs of stromal inflammation) Microbiologic evidence of fungus on smear and or culture media Willing to return for all the follow up visits
Exclusion
- Patients not willing to give consent Patients unable to cooperate for the procedure Patient with impending, or actual perforation or bilateral corneal ulcer or scleral involvement History of previous ocular surgery Evidence of bacterial, parasitic or viral infection or co-infection Previous corneal scar Known allergy to the study medication (drug or preservative) Pregnant or nursing females Immunocompromised patients
Key Trial Info
Start Date :
January 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2018
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT03230058
Start Date
January 1 2017
End Date
September 30 2018
Last Update
July 26 2017
Active Locations (1)
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1
GMRV Campus LV Prasad Eye Insitute
Visakhapatnam, Andhra Pradesh, India