Status:
COMPLETED
MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Complicated Urinary Tract Infection
Pyelonephritis
Eligibility:
All Genders
7-17 years
Phase:
PHASE2
Brief Summary
This study aims to evaluate the safety and tolerability of MK-7625A (ceftolozane/tazobactam) compared with that of meropenem in pediatric participants with cUTI, including pyelonephritis.
Eligibility Criteria
Inclusion
- Has a legally acceptable representative who provides documented informed consent / assent for the trial.
- Ages from birth (defined as \>32 weeks gestational age and ≥7 days postnatal) to \<18 years of age.
- Requires IV antibacterial therapy for the treatment of cUTI.
- Have a pretreatment baseline urine culture specimen obtained within 48 hours before the start of administration of the first dose of study treatment and preferably prior to administration of any potentially therapeutic antibiotics.
- Has pyuria.
- Has clinical signs and/or symptoms of cUTI at the Screening Visit.
- Is not of reproductive potential; but if of reproductive potential agrees to avoid becoming pregnant or impregnating a partner during screening, while receiving study treatment and for at least 30 days after the last dose of study treatment.
- Female of reproductive potential is not pregnant, and not planning to become pregnant within 30 days of the last day of treatment administration; and is nonlactating.
Exclusion
- Is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 30 days prior to the first dose of study treatment in this current trial.
- Has previously participated in any trial of ceftolozane or ceftolozane/tazobactam or has enrolled previously in the current trial and been discontinued.
- Has a history of any moderate or severe hypersensitivity (e.g.anaphylaxis), allergic reaction, or other contraindication to any of the following: β-lactam antibiotics (e.g, penicillins, cephalosporins, and carbapenems), β-lactamase inhibitors (e.g. tazobactam, sulbactam, clavulanic acid, avibactam), or metronidazole.
- Has a history of a cUTI within the past 1 year prior to randomization known to be caused by a pathogen resistant to either IV study treatment.
- Has a concomitant infection at the time of randomization that requires nonstudy systemic antibacterial therapy in addition to IV study treatment or oral step -down therapy.
- Has received potentially therapeutic antibacterial therapy for a duration more than 24 hours during the 48 hours preceding the first dose of study treatment.
- Has any of the following: a) intractable UTI or pyelonephritis infection at baseline that the Investigator anticipates would require more than 14 days of study treatment; b) confirmed fungal urinary tract infection at time of randomization; c) permanent indwelling bladder catheter or instrumentation including nephrostomy; d) current urinary catheter that is not scheduled to be removed before the end of all study treatment; e) complete, permanent obstruction of the urinary tract; f) suspected or confirmed perinephric or intrarenal abscess; g) documented ileal loop reflux; h) suspected or confirmed prostatitis, urethritis, or epididymitis; i) trauma to pelvis/urinary tract.
- Has moderate or severe impairment of renal function.
- Has a seizure disorder or is anticipated to be treated with divalproex sodium or valproic acid during the course of study treatment.
- Is receiving, or is expected to receive, any prohibited medications.
- Has any rapidly progressing disease or immediately life-threatening illness, including acute hepatic failure, respiratory failure, or septic shock.
- Has an immunocompromising condition.
- Has a history of malignancy ≤5 years prior to signing informed consent.
- Is planning to receive suppressive/prophylactic antibiotics with gram-negative activity after completion of study treatment.
Key Trial Info
Start Date :
April 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 3 2020
Estimated Enrollment :
134 Patients enrolled
Trial Details
Trial ID
NCT03230838
Start Date
April 26 2018
End Date
December 3 2020
Last Update
May 6 2023
Active Locations (52)
Enter a location and click search to find clinical trials sorted by distance.
1
Children's Hospital - Los Angeles ( Site 2509)
Los Angeles, California, United States, 90027
2
Children's Hospital of Orange County ( Site 2502)
Orange, California, United States, 92868
3
Rady Children's Hospital-San Diego ( Site 2505)
San Diego, California, United States, 92123
4
Ann & Robert H. Lurie Children's Hospital of Chicago ( Site 2519)
Chicago, Illinois, United States, 60611