Status:
COMPLETED
Cardiac MRI in Front Line for the Diagnosis of Coronary Artery Disease as the Etiology of Left Ventricular Dysfunction
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Ischemic Cardiomyopathy
Eligibility:
All Genders
18+ years
Brief Summary
When a patient is newly diagnosed of systolic dysfunction without obvious etiology (such as rhythmic, ischemic, or valvular disease), most of the time a coronary angiography is performed. In this situ...
Detailed Description
Reduced Left Ventricular Ejection Fraction (LVEF) is estimated to be present in 3-7% of the population. With a survival rate between 25-40% at 5 years after a first hospitalization, prognosis of heart...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Left Ventricular Ejection Fraction ≤ 45% on transthoracic echocardiography
- Informed signed consent
- Patient having had a preliminary clinical examination
Exclusion
- Known significant coronary artery stenosis (history of myocardial infarction or coronary artery stenosis).
- Formal indication for coronary angiography other than LV dysfunction (typical angina, acute coronary syndrome, …).
- Obvious etiology for LV dysfunction (valvular, rhythmic…).
- Pregnancy or breastfeeding.
- Other contraindication for CMR (severe allergy to gadolinium known), or coronary artery angiography.
- First diagnosis of LVEF dysfunction \> 8 weeks.
- Non covered patient by the social security, the CMU
- Patients under guardianship, or unable to give consent
Key Trial Info
Start Date :
May 15 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
415 Patients enrolled
Trial Details
Trial ID
NCT03231189
Start Date
May 15 2018
End Date
August 31 2024
Last Update
August 27 2025
Active Locations (1)
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1
Hopital Bichat Claude-Bernard
Paris, France, 75018