Status:
COMPLETED
Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy
Lead Sponsor:
KK Women's and Children's Hospital
Conditions:
Ketamine
Anesthesia
Eligibility:
FEMALE
21+ years
Phase:
PHASE2
Brief Summary
The investigators want to investigate the effect of low dose S+ ketamine compared to placebo on cumulative morphine consumption at 24 hours in 90 women undergoing open abdominal hysterectomy with remi...
Detailed Description
A number of 90 American Society of Anesthesiologists (ASA) I and II patients undergoing elective open abdominal hysterectomies will be randomly distributed in two groups of 45 patient's each and assig...
Eligibility Criteria
Inclusion
- Female ASA I/II patients above age of 21 years old scheduled gynecological open surgery for benign condition (fibroids, adenomyosis), who are willing and able to give written informed consent for participation in this study.
Exclusion
- Contraindications to the use of S+ ketamine, as listed in the product label e.g. untreated or insufficiently treated thyroid hyperfunction, unstable angina pectoris or myocardial infarction within the last 6 months, diseases of the central nervous system, increased intraocular pressure and perforating ocular injuries, surgical procedures in the upper respiratory tract;
- History of drug or alcohol abuse;
- Regular use of analgesics, or use of opioids within 12 hours of surgery;
- Chronic use of benzodiazepine or neuroleptics;
- Thyroid replacement hormone;
- History of ischaemic heart disease, hypertension, psychiatric disorder;
- BMI\> 30kg/m2;
- Laparoscopic surgery converted to open surgery;
- Pregnant or breast feeding females.
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2016
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03231683
Start Date
March 1 2014
End Date
May 1 2016
Last Update
July 27 2017
Active Locations (1)
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1
Kk Women'S and Children'S Hospital
Singapore, Singapore, 229899