Status:
COMPLETED
Intrathecal Morphine for Unilateral Total Knee Arthroplasty
Lead Sponsor:
Mahidol University
Conditions:
Primary Osteoarthritis of Knee Nos
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study evaluates postoperative numerical pain score and systemic opioid requirement within 48 hours for unilateral total knee arthroplasty. Comparing among 3 groups of intrathecal morphine; 0,50, ...
Detailed Description
Intrathecal opioid is effective postoperative analgesia for orthopedic lower extremity surgery. However there are some limitations such as nausea, vomiting, pruritus, dizziness. Nowadays multimodal an...
Eligibility Criteria
Inclusion
- Aged more than 18 years old undergoing unilateral total knee arthroplasty
- American Society of Anesthesiologists physical status classification 1-3
Exclusion
- Participants deny to enroll the study
- Allergy to local anesthetics, opioid and NSAIDs
- Hepatic disease
- Contraindication for neuraxial block or adductor canal block
- Uncontrolled cardiovascular disease
- Creatinine clearance less than 50 ml/min
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2019
Estimated Enrollment :
131 Patients enrolled
Trial Details
Trial ID
NCT03232957
Start Date
August 1 2017
End Date
July 31 2019
Last Update
May 24 2021
Active Locations (1)
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1
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand, 10700