Status:
ACTIVE_NOT_RECRUITING
Safety and Pharmacokinetics of Cemiplimab Anti-programmed Death-ligand 1 (Anti-PD-1) and Other Agents in Japanese Adult Patients With Advanced Malignancies
Lead Sponsor:
Regeneron Pharmaceuticals
Conditions:
Advanced Malignancies
Eligibility:
All Genders
20+ years
Phase:
PHASE1
Brief Summary
Part 2 Cohorts A and C This study is being conducted to test the safety and pharmacokinetics of cemiplimab in patients with lung cancer. The study is also being conducted to test if cemiplimab, alone ...
Eligibility Criteria
Inclusion
- Key
- Disease types under study:
- Part 1: Histologically or cytologically confirmed diagnosis of malignancy with no alternative standard-of-care therapeutic option
- Part 2: Patients with histologically or cytologically documented squamous or non-squamous NSCLC with stage IIIB or IIIC or stage IV disease who received no prior systemic treatment for recurrent or metastatic NSCLC.
- Patients in Part 2 NSCLC cohorts must have available archival or newly obtained formalin-fixed tumor tissue from a metastatic/recurrent site, which has not previously been irradiated.
- ECOG (Eastern Cooperative Oncology Group) PS (Performance status) ≤1 (Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature \[eg, light housework or office work\]). Note: Patients with ECOG PS \>1 are ineligible.
- Patients must have been born in Japan, and their biological parents and grandparents must all have been of Japanese origin
- Willing and able to comply with clinic visits and study-related procedures
- For Part 2, Cohorts D and E: Available tissue for retrospective testing using assay performed by a central laboratory, as specified in the study manual.
- Key
Exclusion
- Ongoing or recent (within 5 years) evidence of significant autoimmune disease that requires treatment with systemic immunosuppressive treatments, which may suggest risk for Immune-mediated adverse event (imAE)s. The following are not exclusionary: vitiligo, childhood asthma that has resolved, residual hypothyroidism that requires only hormone replacement or psoriasis that does not require systemic treatment.
- Untreated brain metastasis (es) that may be considered active. Patients with previously treated brain metastases may participate provided they are stable, there is no evidence of new or enlarging brain metastases, and the patient does not require any systemic corticosteroids for management of brain metastases within 4 weeks prior to the first dose of cemiplimab.
- Immunosuppressive corticosteroid doses (\>10 mg prednisone daily or equivalent) within 4 weeks prior to the first dose of cemiplimab.
- Any positive test (ribonucleic acid (RNA) or Deoxyribonucleic acid (DNA) by polymerase chain reaction) for hepatitis B, hepatitis C, or human immunodeficiency virus indicating uncontrolled active or chronic infection.
- History of pneumonitis or interstitial lung disease
- Surgery within 1 month of first dose and radiation therapy within 2 weeks of first dose
- Completed palliative radiation therapy within the prior 2 weeks or has not recovered from any medically significant radiation-related Adverse Event (AE)
- Patients that have never smoked, defined as smoking ≤100 cigarettes in a lifetime (Part 2)
- Patients with tumors tested positive for epidermal growth factor receptor (EGFR) gene mutations, anaplastic lymphoma kinase (ALK) gene translocations, or ROS1 fusions (Part 2)
- Note: Other protocol defined inclusion/exclusion criteria apply.
Key Trial Info
Start Date :
June 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2027
Estimated Enrollment :
146 Patients enrolled
Trial Details
Trial ID
NCT03233139
Start Date
June 21 2017
End Date
September 30 2027
Last Update
April 2 2025
Active Locations (20)
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1
National Hospital Organization Nagoya Medical Center
Nagoya, Aichi-ken, Japan, 460-0001
2
Kurume University Hospital
Kurume, Fukuoka, Japan, 830-0011
3
Gunma Prefectural Cancer Center
Ōta, Gunma, Japan, 373-8550
4
Kobe City Medical Center General Hospital
Kobe, Hyōgo, Japan, 650-0047