Status:
COMPLETED
Trial of Respiratory Infections in Children for Enhanced Diagnostics
Lead Sponsor:
Karolinska Institutet
Collaborating Sponsors:
Stockholm South General Hospital
Science for Life Laboratory
Conditions:
Community-acquired Pneumonia
Eligibility:
All Genders
28-59 years
Brief Summary
The overall aim of the TREND study is to improve the differential diagnosis of bacterial and viral etiology in children below 5 years of age with clinical community acquired pneumonia. Specific objec...
Detailed Description
Background: Respiratory viral and bacterial infections are hard to distinguish clinically, and many children with viral infections receive unnecessary treatment with antibiotics, which contributes to ...
Eligibility Criteria
Inclusion
- Cases:
- (all inclusion criteria to be met to be eligible for participation in the study).
- Age 28 days to 59 months
- Reported and/or observed breathing troubles OR cough
- Observed age-adjusted tachypnea (≥50 breaths/min in children 1-12 months, ≥40/min in children \>1year) OR chest in-drawings
- Written informed consent
- Controls:
- (all inclusion criteria to be met to be eligible for participation in the study).
- Age 28 days to 59 months
- Minor surgical or orthopedic disease (elective (e.g. hand surgery) or acute) or minor surgical disease, e.g. minor trauma (excluding e.g. appendicitis, major burns, major trauma)
- Written informed consent
Exclusion
- Cases:
- Previously included as case in the study
- Hospitalized during last 14 days
- Controls:
- Symptoms of respiratory disease 7 days before enrollment
- Previously included as control in the study
- Hospitalized during last 14 days
Key Trial Info
Start Date :
November 20 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 9 2019
Estimated Enrollment :
376 Patients enrolled
Trial Details
Trial ID
NCT03233516
Start Date
November 20 2017
End Date
December 9 2019
Last Update
November 23 2020
Active Locations (1)
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1
Sachs' Children and Youth Hospital
Stockholm, Sweden