Status:
UNKNOWN
COmprehensive Remote Ischemic Conditioning in Myocardial Infarction
Lead Sponsor:
China National Center for Cardiovascular Diseases
Conditions:
Myocardial Infarction, Anterior Wall
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The primary objective of the CORIC-MI trial is to evaluate whether comprehensive (per, post plus delayed) remote ischemic conditioning (CORIC) as an adjunctive therapy in patients with ST-elevation my...
Detailed Description
ST-segment elevation myocardial infarction (STEMI) is a leading cause of mortality and morbidity worldwide. Rapid admission and acute interventional treatment combined with modern antithrombotic pharm...
Eligibility Criteria
Inclusion
- Suspected anterior STEMI: new ST-elevation \> 0.1 millivolt (mV) (≥ 0.2 mV in men or ≥ 0.15 mV in women in leads V2-V3) in \> two contiguous leads in V1-V6; new or presumed new left bundle branch block;
- Symptom onset no more than 12 h before presentation and planned primary PCI;
- Age 18 to 75 years;
- Willingness and capability to provide informed consent.
Exclusion
- Previous anterior myocardial infarction;
- Previous coronary artery bypass graft (CABG);
- Myocardial infarction or stroke within the previous 30 days;
- Treatment with thrombolysis within the previous 30 days;
- Cardiogenic shock;
- Thrombolysis in myocardial infarction (TIMI) flow grade 2 or 3 at coronary angiography;
- Coronary anatomy or mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation) warranting emergent surgery;
- Inability to obtain TIMI flow grade ≥ 2;
- Conditions precluding use of RIC (paresis of lower limb, known severe peripheral artery disease or evidence of lower limb ischemia, and etc.);
- Life expectancy of less than 12 months due to non-cardiac disease such as known malignancy or other comorbid conditions;
- Contraindications to CMR;
- Treated with therapeutic hypothermia before admission;
- Pregnancy and lactating women;
- Participation in another interventional trial.
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2020
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03233919
Start Date
August 1 2017
End Date
January 30 2020
Last Update
April 24 2018
Active Locations (1)
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1
Chinese Academy of Medical Sciences, Fuwai Hospital
Beijing, Beijing Municipality, China, 100037