Status:
COMPLETED
Deferiprone to Delay Dementia (The 3D Study)
Lead Sponsor:
Neuroscience Trials Australia
Collaborating Sponsors:
The Florey Institute of Neuroscience and Mental Health
Conditions:
Mild Cognitive Impairment
Prodromal Alzheimer's Disease
Eligibility:
All Genders
65+ years
Phase:
PHASE2
Brief Summary
This study is a phase 2, randomised, placebo-controlled, multicentre study to investigate the safety and efficacy of Deferiprone in participants with Prodromal Alzheimer's Disease (pAD) and Mild Alzhe...
Detailed Description
This Phase II study is designed as a randomised, double-blinded, placebo controlled, multi-centre study for subjects with evidence of amyloid positive pAD or mAD. Participants will be assigned random...
Eligibility Criteria
Inclusion
- Able to provide written informed consent in accordance with federal, local and institutional guidelines. For subjects unable to provide written consent, consent will be provided by the Person Responsible per local regulations.
- Age ≥65 years, or ≥55 years if they have been diagnosed by a psychiatrist or neurologist with dementia, or if they have a validated previous positive amyloid PET scan.
- Weight between 40 and 120 kg
- Have an available caregiver
- Have ≥ 6 years of education (any) and able to follow testing instructions.
- Have visual and auditory acuity sufficient to perform neuropsychological testing.
- Have prior evidence of AD pathology, by a positive amyloid assessment, or amyloid PET scan.
- Demonstrate abnormal memory function in the last 6 months or at screening: International Shopping List Test (ISLT) \>1.5 SD below the age adjusted mean
- Subjective or clinical history of retrospective cognitive decline ≥6 months
- Evidence of mild symptomatology, as defined by a screening MMSE score of ≥ 20 points
- Meet National Institute on Ageing/Alzheimer's Association Diagnostic Guidelines for Alzheimer's Disease (NIAAA) research criteria for mAD or pAD
- If receiving medication for symptomatic AD, have a stable dosing regimen for 3 months prior to screening.
- Females of Child Bearing Potential (FCBP) must have confirmed negative serum pregnancy test within the 21 days prior to randomization.
- FCBP and male subjects who are sexually active with FCBP must agree to use highly effective contraception during the study and until 90 days after the last dose of treatment (for sexually active male participants whose partners are FCBP) or until 30 days after the last dose of treatment (for women of childbearing potential participants).
Exclusion
- Clinically significant haematological disorder, including moderate or severe anaemia (blood haemoglobin \<110 g/L, WHO definition)
- Iron deficiency (serum ferritin \< 10 ng/mL)
- Clinically significant abnormal haematological results (sufficiently outside the normal range to warrant further investigation). Mild anaemia (haemoglobin ≥110 g/L) is not an exclusion.
- Clinically significant abnormal renal or liver function results (sufficiently outside the normal range to warrant further investigation)
- Presence of non-AD condition that may affect cognition, such as but not limited to Parkinson's Disease (PD), normal pressure hydrocephalus, sleep apnoea requiring O2 treatment
- Clinically evident vascular disease that could potentially affect the brain, such as but not limited to significant carotid or vertebral stenosis, aortic aneurysm, cerebral haemorrhage
- History of any stroke in the past 2 years, or transient ischemic attack within the last 6 months
- History of persistent neurologic deficit, intracranial tumour or structural brain damage
- History of infection that could affect brain function (eg HIV and syphilis)
- Autoimmune disorders that potentially cause progressive neurologic disease with associated cognitive deficits, such as but not limited to multiple sclerosis, lupus
- Major psychiatric illness (depression is acceptable if patient has not had an episode within the past year or is considered in remission or controlled by treatment)
- A history of relapsing neutropenia.
- Presence of agranulocytosis or with a history of agranulocytosis
- Known hypersensitivity to DFP or excipients.
- Alcohol and/or substance abuse
- MRI evidence of clinically-significant cerebrovascular pathology. Focal white matter lesions, ≤ 2 lacunar infarcts in non-critical sites and other minor pathology assessed by the investigator to not be causing the current cognitive impairment, will not lead to exclusion.
- Active major medical illness
- FCBP not using adequate method of contraception or who is pregnant or nursing
- Inability to provide informed consent
- Participation in another clinical trial within 3 months prior to inclusion in the study
- Subjects for whom MRI is contraindicated (severe claustrophobia, pacemaker, incompatible surgical material, unmovable electronic pump implant)
- Negative amyloid PET scan or CSF in the last 2 years.
- Hospital Anxiety and Depression Scale (scores \> 8/21 are disqualified).
- Subject cannot commit to regular blood tests with the interval between tests not exceeding 10 days from the scheduled visit for the duration of the study.
- Subject has planned surgery which does not permit regular blood tests with the interval between tests not exceeding 10 days from the scheduled visit.
Key Trial Info
Start Date :
January 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 23 2023
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT03234686
Start Date
January 19 2018
End Date
February 23 2023
Last Update
July 3 2024
Active Locations (8)
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1
KaRa Institute of Neurological Diseases
Macquarie Park, New South Wales, Australia, 2113
2
Hunter New England Local Health District
Waratah, New South Wales, Australia, 2298
3
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
4
Austin Health
Heidelberg, Victoria, Australia, 3084