Status:
UNKNOWN
Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants
Lead Sponsor:
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Conditions:
nCPAP
BiPAP
Eligibility:
All Genders
5-6 years
Phase:
NA
Brief Summary
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -...
Detailed Description
Invasive ventilation is related to development of adverse pulmonary and nonpulmonary outcomes in ventilated infants. Various modes of noninvasive respiratory support are being increasingly used to min...
Eligibility Criteria
Inclusion
- 1\. Gestational age (GA) is from 26 to 37 weeks;
- 2\. Diagnosis of respiratory distress syndrome. The diagnosis of respiratory distress syndrome will be based on clinical manifestations (tachypnea, nasal flaring and or grunting) and chest X-ray findings;
- 3\. Respiratory distress syndrome Silverman score \>5;
- 4\. Informed parental consent has been obtained.
Exclusion
- 1\. Severe respiratory distress syndrome requiring early intubation according to the American Academy of Pediatrics guidelines for neonatal resuscitation;
- 2\. Major congenital malformations or complex congenital heart disease;
- 3\. Group B hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage;
- 4\. Cardiopulmonary arrest needing prolonged resuscitation;
- 5\. transferred out of the neonatal intensive care unit without treatment.
Key Trial Info
Start Date :
August 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 15 2022
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03235661
Start Date
August 15 2017
End Date
December 15 2022
Last Update
February 16 2021
Active Locations (1)
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1
Department of Pediatrics, Daping Hospital, Third Military Medical University
Chongqing, Chongqing Municipality, China, 400042