Status:
UNKNOWN
Establishment of a Biomarkers-based Early Warning System of Acute Respiratory Distress Syndrome (ARDS)
Lead Sponsor:
Mingdong Hu
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18-80 years
Brief Summary
The aim of the investigators 'study is to investigate the relationship between the biomarkers (e.g. protein markers, genetic polymorphisms and epigenetic markers) and the onset of ARDS. In this study,...
Detailed Description
The investigators studied patients at high risk of acute respiratory distress syndrome (ARDS) and ARDS patients. The patients with ARDS were the case group, and the patients without ARDS were the cont...
Eligibility Criteria
Inclusion
- High-risk cases ARDS inclusion criteria:
- Acute onset (within 1 weeks)
- Pneumonia,Aspiration,Sepsis,Acute pancreatitis,Shock,High-risk trauma and other unexpected severe diseases.
- Pao2/Fio2\>300mmhg
- 18 to 80 years old
- The subjects agreed to sign the informed consent
- ARDS Inclusion criteria:
- Acute onset (within 1 weeks)
- Pneumonia,Aspiration,Sepsis,Acute pancreatitis,Shock,High-risk trauma and other unexpected severe diseases.
- Pao2/Fio2\<300mmhg
- 18 to 80 years old
- The subjects agreed to sign the informed consent
Exclusion
- patients who developed ARDS before initial evaluation or blood collection
- patients who were rehospitalized
- the hospital stay was shorter than 7 days, and it was unfeasible to determine the clinical outcome
- patients who died within 6h of admission
- patients had a history of chronic interstitial lung disease
- patients with an age of less than 18 years old
- Patients were immunodeficiency (eg, eukaemia) or treated with cytotoxic drugs
- patients who were pregnant
- patients who were refused to join.
Key Trial Info
Start Date :
September 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
376 Patients enrolled
Trial Details
Trial ID
NCT03236272
Start Date
September 15 2017
End Date
December 31 2020
Last Update
March 25 2020
Active Locations (1)
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1
Center of Respiratory and Critical Care Medicine，Department Of Gerontology and Secret Service Medicine, Xinqiao Hospital, Third Military Medical University
Chongqing, China