Status:
UNKNOWN
Remote Ischaemic Conditioning on Blood Pressure Control in Chronic Kidney Disease Patients
Lead Sponsor:
Singapore General Hospital
Collaborating Sponsors:
Duke-NUS Graduate Medical School
Conditions:
Chronic Kidney Diseases
Hypertension
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
Chronic kidney disease (CKD) is one of the leading causes of death and disability in Singapore and worldwide. Hypertension is commonly inadequately controlled in patients with CKD and this is associat...
Detailed Description
Chronic kidney disease (CKD) is one of the leading causes of death and disability in Singapore and worldwide. CKD patients often suffer with inadequately controlled hypertension, the presence of which...
Eligibility Criteria
Inclusion
- Signed informed consent
- Aged 21 years and older
- CKD (all stages 1-4)
- On treatment for hypertension and automated office BP (AOBP) ≥ 140mmHg (this will be determined by an automated oscillometric BP device)
Exclusion
- Patients with polycystic kidney disease
- Atrial fibrillation
- Patients on long-acting sulphonylureas (eg glibenclamide) or nicorandil (as these medications may interfere with the protective effect of CRIC).
- Patients recruited into another study which may impact on this study.
- Symptomatic peripheral arterial disease affecting the upper limbs (given nature of upper-limb CRIC protocol).
- Renal transplant / Dialysis patients
- Pregnant patients
- Patients on any anti-coagulant medications (e.g. Warfarin)
- For echo sub-study only: Prior myocardial infarction, BMI \> 30kg/m2, known severe acrdiac valve disease, known severely impaired LVEF \<35%
Key Trial Info
Start Date :
November 28 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2020
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT03236350
Start Date
November 28 2017
End Date
June 30 2020
Last Update
September 23 2019
Active Locations (1)
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1
Singapore General Hospital
Singapore, Singapore, 169608