Status:
COMPLETED
Menopause Effects on Vascular Function
Lead Sponsor:
University of Delaware
Collaborating Sponsors:
American Heart Association
Conditions:
Cardiovascular Risk Factor
Eligibility:
FEMALE
18-65 years
Phase:
NA
Brief Summary
The purpose of the study is to identify the independent effect of estradiol (E2) on endothelin-1 (ET-1) mediated vasomotor function in women. The study is the first step in recognizing the impact of o...
Detailed Description
Cardiovascular disease (CVD) is the leading cause of death in women (Roger, Go, Lloyd, Adams, Berry, Brown, et al, 2011). Functional changes in the microvasculature occur with aging and precede athero...
Eligibility Criteria
Inclusion
- Young women between 18-35 years of age with regular menstrual cycles
- Postmenopausal women between 50-65 years of age and no more than 10 years past menopause
- Non-smoking
- BMI \< 30 kg/m2
- Free from known disease (heart disease, cancer, diabetes)
Exclusion
- Current use of hormone therapy or within the past year
- Women using Depo-provera or an intra-uterine device (IUD)
- Pregnant, are planning on becoming pregnant, or are breast- feeding.
- History of stable or unstable angina
- Diabetes
- Neurological disease
- Lung disease
- Kidney or liver disease
- Cancer
- Hysterectomy
- Peripheral vascular disease
- History of blood clots
- Heart disease
- Fibroids
- High blood pressure
- Stroke
Key Trial Info
Start Date :
July 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2022
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT03236545
Start Date
July 1 2016
End Date
November 1 2022
Last Update
November 14 2022
Active Locations (1)
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1
University of Delaware
Newark, Delaware, United States, 19716