Status:
WITHDRAWN
The Role of the Thymus in Type I Diabetes.
Lead Sponsor:
University Hospital, Toulouse
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Centre National de la Recherche Scientifique, France
Conditions:
Type1 Diabetes
Eligibility:
All Genders
6-12 years
Phase:
NA
Brief Summary
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases. Thi...
Detailed Description
In the thymus of an animal model of type I diabetes, the population of regulatory T cells expresses a repertoire of antigen receptors that is approximately ten-fold less diverse than that found in mic...
Eligibility Criteria
Inclusion
- type I diabetes patient
- having at least one age-matched sibling (healthy control)
Exclusion
- other immunopathology
- treatment with any anti-inflammatory or immunosuppressive drugs
- puberty
- legal protection
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03236558
Start Date
March 1 2018
End Date
March 1 2019
Last Update
April 1 2020
Active Locations (1)
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1
CHU de Toulouse
Toulouse, Midi-Pyrénées, France, 31059