Status:
COMPLETED
Effects of Sedation on Transpulmonary Pressure and Lung Homogenous
Lead Sponsor:
Southeast University, China
Conditions:
ARDS
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The acute respiratory distress syndrome (ARDS) is characterized by severe respiratory failure. Open Lung and Lung Protective Strategy have been proved to improve mortality of ARDS patients. Preserving...
Detailed Description
Further study details as provided by Nanjing Zhong-da Hospital, School of Medicine, Southeast University
Eligibility Criteria
Inclusion
- ARDS group patient (1) Acute onset of all of the following criteria within a 48-hour period:
- Requires positive pressure ventilation through an endotracheal tube
- Bilateral infiltrates consistent with edema on frontal chest radiograph, with a duration of no more than 7 days
- PaO2/FiO2 less than 300 while receiving positive end-expiratory pressure (PEEP) at more than 5 cm H2O for at least 4 hours, with a duration of no more than 7 days
- No clinical evidence of left atrial hypertension (2) Hemodynamics stable (dopamine \<10ug/kg•min or norepinephrine \<10ug/kg)
- Surgical patient Surgical patient requires positive pressure ventilation through an endotracheal tube PaO2/FiO2 more than 300 Hemodynamics stable (dopamine \<10ug/kg•min or norepinephrine \<10ug/kg)
Exclusion
- Age younger than 18 years or older than 85 years
- Cardiac failure
- Known pregnancy
- Increased intracranial pressure
- Severe neuromuscular disease
- Recent injury or other pathologic condition of the esophagus
- Pneumothorax
- Pleural effusion
- Diaphragmatic hernia
- Severe chronic respiratory disease
- End-stage chronic organ failure
- Expected survival of less than 24 hours
- Participation in another interventional study
- Attending physician declines to give consent for participant to enroll
- Patient or surrogate declines or is unable to give consent
Key Trial Info
Start Date :
May 31 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 18 2018
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT03237806
Start Date
May 31 2015
End Date
March 18 2018
Last Update
March 20 2018
Active Locations (1)
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1
Department of Critical Care Medicine, Nanjing Zhong-da Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China, 210009