Status:
UNKNOWN
Efficacy of High-intensity NPPV and Low-intensity NPPV in Patients With Chronic Hypercapnic COPD
Lead Sponsor:
The First Affiliated Hospital of Guangzhou Medical University
Conditions:
COPD
Hypercapnic Respiratory Failure
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
High-intensity noninvasive positive pressure ventilation (NPPV), which can well improve the gas exchange and reduce the work of breathing of patients, is a new strategy targeted at maximally reducing ...
Eligibility Criteria
Inclusion
- Clinically stable with chronic hypercapnic COPD (baseline arterial carbon dioxide pressure (PaCO2) of 50 mmHg or higher, measured resting in a sitting position and breathing room air without having used NPPV for at least 1 hour)
Exclusion
- other lung/pleural diseases or thoracic deformity
- severe heart failure (New York Heart Association class IV), severe dysrhythmia
- unstable angina, or malignant comorbidity
- obesity (BMI ≥ 35 kg/m²)
- severe obstructive sleep apnea syndrome
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT03238014
Start Date
August 1 2017
End Date
May 1 2020
Last Update
February 5 2020
Active Locations (1)
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1
Guangzhou Institute of Respiratory Disease
Guangzhou, Guangdong, China, 510000