Status:
ACTIVE_NOT_RECRUITING
Liver Glycogen and Hypoglycemia in Humans
Lead Sponsor:
Jason Winnick
Conditions:
Hypoglycemia; Iatrogenic
Eligibility:
All Genders
21-40 years
Phase:
PHASE1
Brief Summary
The purpose of this research study is to learn more about how sugar levels in the liver affect the ability of people both with and without type 1 diabetes. People with type 1 diabetes do not make thei...
Detailed Description
There is universal agreement that iatrogenic hypoglycemia is the single most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes (T1D). The typical patien...
Eligibility Criteria
Inclusion
- Males and females of any race or ethnicity.
- Aged 21-40 years.
- Non-obese (BMI \<28 kg/m2).
Exclusion
- Pregnant women.
- Cigarette smoking.
- Taking inflammation-targeting steroids (e.g., prednisone).
- Taking medications targeting adrenergic signaling (e.g., beta-blockers, bronchodilators).
- Abnormal hematocrit or electrolyte levels.
- The presence of cardiovascular or peripheral vascular disease.
- The presence of neuropathy, retinopathy or nephropathy.
- Any metal in the body that would make magnetic resonance spectroscopy dangerous.
Key Trial Info
Start Date :
August 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03241706
Start Date
August 2 2018
End Date
May 31 2028
Last Update
July 25 2025
Active Locations (1)
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1
University of Cincinnati
Cincinnati, Ohio, United States, 45267