Status:
COMPLETED
Neuroactive Steroids in Acute Ischemic Stroke
Lead Sponsor:
Hospital Militar Central, Argentina
Conditions:
Ischemic Stroke
Cortisol; Hypersecretion
Eligibility:
All Genders
60-90 years
Brief Summary
Acute ischemic stroke (AIS) represents an economical challenge for health systems all over the globe. Despite increasing knowledge of the pathophysiology of AIS, there is no satisfactory treatment to ...
Detailed Description
Acute Ischemic Stroke (AIS) is one of the main causes of functional deterioration all over the world. Thus, 26% of patients older than 65 years still show limitations of daily activities 6 months afte...
Eligibility Criteria
Inclusion
- Age between 60 and 90 years.
- Agreeing to participate in the study.
- Acute Ischemic Stroke of anterior vascular territory and/or posterior vascular territory whithin 24 hours of onset.
- Nine or more points in the Glasgow Coma Scale.
- Female patients in menopause.
- Patients without cognitive impairment before AIS according to family reference.
- Acceptance of the next of kin proxy in case the participant has sensory impairment.
Exclusion
- Age \<60 or \> 90 years.
- Hemorrhagic Stroke.
- Transient ischemic attack (TIA).
- Acute Ischemic Stroke after 24 hours of onset.
- Hormonal replacement therapy.
- Immunosuppressive therapy in the last month before AIS (example corticosteroids).
- Acute infection (Example, pneumonia, urinary tract infection).
- Diagnosis of oncologic disease in the last month before AIS.
- Diagnosis of endocrinologic disease in the last month before AIS.
- Acute or long-term psychiatric illness.
- No agreement to participate in the study.
- Eight or less points in the Glasgow Coma Scale.
- Female patients with menstrual cycle or in the perimenopause.
- Patients with kidney or hepatic illness.
- Patients with cognitive impairment before AIS.
Key Trial Info
Start Date :
April 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03242304
Start Date
April 1 2016
End Date
December 1 2016
Last Update
August 8 2017
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