Status:
COMPLETED
The Utility of 18F-DOPA-PET in the Treatment of Recurrent High-grade Glioma
Lead Sponsor:
Mayo Clinic
Conditions:
Glioma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This proposal is for a pilot study comparing volumes of 18F-DOPA-PET avidity with contrast enhancement and T2 FLAIR on MRI. Investigators then plan to compare patterns of failure with target volumes, ...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age \> or equal to 18 years
- ECOG PS \< or equal to 3
- Histologically confirmed or radiographic evidence of recurrent/progressive glioma.
- History of radiation therapy to the brain for prior diagnosis of glioma
- Planned radiation treatments at Mayo Clinic Rochester
- Provide informed written consent
- Willing to sign consent onto the Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking study, IRB number 15-000136 (blood draw optional)
- Willing to return to enrolling institution for follow-up during Active Monitoring Phase of the study.
- Exclusion Criteria
- More than one prior course of radiotherapy or prior prescription doses exceeding 60 Gy to re-irradiation target volumes
- Unable to undergo MRI scans with contrast
- Unable to undergo an 18F-DOPA-PET scan (e.g., Parkinson's Disease, taking anti dopaminergic, or dopamine agonist medication or less than 6 half-lives from discontinuance of dopamine agonists.)
- Note: Other potentially interfering drugs: amoxapine, amphetamine, benztropine, buproprion, buspirone, cocaine, mazindol, methamphetamine, methylphenidate, norephedrine, phentermine, phenylpropanolamine, selegiline, paroxetine, citalopram, and sertraline). If a patient is on any of these drugs, list which ones on the On-Study form.
- Any of the following:
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate contraception
Exclusion
Key Trial Info
Start Date :
September 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 16 2021
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03242824
Start Date
September 29 2017
End Date
June 16 2021
Last Update
March 14 2023
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905