Status:
WITHDRAWN
Silver Nanoparticle Investigation for Treating Chronic Sinusitis
Lead Sponsor:
Washington University School of Medicine
Conditions:
Chronic Rhinosinusitis (Diagnosis)
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Chronic rhinosinusitis is a highly prevalent disease resulting in high economic burden. Effective therapeutic options are needed. Rhinosinusitis-related biofilms are a likely contributor to recalcitra...
Eligibility Criteria
Inclusion
- Twelve (12) weeks or longer of two or more of the following signs and symptom consistent with chronic rhinosinusitis (CRS):
- mucopurulent drainage (anterior, posterior, or both), nasal obstruction (congestion), facial pain-pressure-fullness, or decreased sense of smell
- AND inflammation is documented by one or more of the following findings:
- purulent (not clear) mucus or edema in the middle meatus or ethmoid region
- polyps in nasal cavity or the middle meatus
- and/or radiographic imaging showing inflammation of the paranasal sinuses
Exclusion
- Unable to speak English
- History of nasal or sinus surgery within past 6 weeks
- History of comorbid ciliary dyskinesia, cystic fibrosis or any other mucociliary condition
- Dependence on prolonged corticosteroid therapy for comorbid condition
- History of renal impairment
- History of cerebrospinal fluid leak
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03243201
Start Date
January 1 2018
End Date
December 1 2018
Last Update
May 11 2018
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