Status:
COMPLETED
BRS and Outcomes in Cardiothoracic Surgery
Lead Sponsor:
Duke University
Conditions:
Pain, Postoperative
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how l...
Detailed Description
The purpose of this study is to determine if preoperative baroreceptor sensitivity (BRS) correlates with major outcomes after cardiac and thoracic surgery, including acute and chronic pain, atrial arr...
Eligibility Criteria
Inclusion
- \>= 18 years of age
- Undergoing cardiac (coronary artery bypass grafting \[CABG\], CABG + valve, or valve only) or thoracic (video-assisted thoracoscopic \[VATS\] approach to lobectomy) surgery
Exclusion
- Any preexisting pain condition (defined as pain of \>=3 months duration prior to enrollment)
- Pain at the time of enrollment interview
- Need for preoperative analgesics
- Preexisting chronic or paroxysmal atrial fibrillation
- Preexisting atrial or ventricular arrhythmia
- Need for preoperative anti-arrhythmic medication
- History of symptomatic cerebrovascular disease (e.g., prior stroke) with residual deficits
- Alcoholism (\>2 drinks/day)
- Psychiatric illness (any clinical diagnosis requiring therapy)
- Drug abuse (any illicit drug use in the preceding 3 months before surgery)
- Hepatic insufficiency (liver function tests \> 1.5 times the upper limit of normal)
- Severe pulmonary insufficiency (home oxygen)
- Renal failure (serum creatinine \>2.0 mg/dL)
- Non-English speaking
- Unable to read
- Participants who score \<24 on baseline Mini Mental State examination
Key Trial Info
Start Date :
September 15 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2022
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT03243279
Start Date
September 15 2017
End Date
May 31 2022
Last Update
July 21 2022
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710