Status:
ACTIVE_NOT_RECRUITING
A Phase 1 Study of CD22-CAR TCell Immunotherapy for CD22+ Leukemia and Lymphoma
Lead Sponsor:
Seattle Children's Hospital
Conditions:
Leukemia
Eligibility:
All Genders
1-26 years
Phase:
PHASE1
Brief Summary
Patients with relapsed or refractory leukemia often develop resistance to chemotherapy and some patients who relapse following CD19 directed therapy relapse with CD19 negative leukemia. For this reaso...
Eligibility Criteria
Inclusion
- First 3 subjects: male and female subjects age ≥ 18 years and \< 27 years
- Subsequent subjects: 12 months of age and \<27 years of age at the time of study enrollment
- Disease status (one of the following):
- If post-allogeneic hematopoetic cell transplant (HCT): confirmed CD22+ leukemia recurrence, defined as ≥0.01% disease
- If Relapse/Refractory status with no prior history of allogeneic HCT, one of:
- 2nd or grater marrow relapse, with or without extramedullary disease
- 1st marrow relapse at end of 1st month of re-induction with marrow having ≥0.01% blasts by morphology and/or MPF
- Primary Refractory, defined as \>5% blasts by multi-parameter flow after ≥2 separate induction regimens
- Subject has indication for HCT but is ineligible, inclusive of persistent minimal residual disease
- CD22+ Lymphoma refractory or relapsed with no known curative therapies available
- Asymptomatic from CNS involvement, if present, and have a reasonable expectation that disease burden can be controlled in the interval between enrollment and T-cell infusion. Subjects with significant neurologic deterioration will not be eligible for T-cell infusion until stabilized.
- Free from active GVHD and off immunosuppressive GVHD therapy for 4 weeks.
- Lansky or Karnofsky performance score of ≥50
- Life expectancy of \>8 weeks
- Recovered from acute toxic effects of all prior chemotherapy, immunotherapy, and radiotherapy
- ≥7 days post last chemotherapy administration (excluding intrathecal or maintenance chemotherapy)
- ≥7 days post last systemic corticosteroid administration
- No prior virotherapy
- Adequate organ function
- Adequate laboratory values
- Patients of childbearing/fathering potential must agree to use highly effective contraception
- Signed a written consent
Exclusion
- Presence of active clinically significant CNS dysfunction
- Pregnant or breastfeeding
- Unable to tolerate apheresis procedure, including placement of temporary apheresis line if required
- Presence of active malignancy other than CD22+ leukemia or lymphoma
- Presence of active severe infection
- Presence of any concurrent medical condition that would prevent the patient from undergoing protocol-based therapy
- Presence of primary immunodeficiency/bone marrow failure syndrome
- Unwilling to participate in 15-year follow-up period that is required if CAR T cell therapy is administered
Key Trial Info
Start Date :
July 27 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2035
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03244306
Start Date
July 27 2017
End Date
July 1 2035
Last Update
June 17 2025
Active Locations (1)
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1
Seattle Children's Hospital
Seattle, Washington, United States, 98105