Status:

COMPLETED

Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA

Lead Sponsor:

Cairo University

Conditions:

Diabetic Macular Edema

Ischemic Maculopathy

Eligibility:

All Genders

18+ years

Phase:

PHASE4

Brief Summary

Anti-vascular endothelial growth factor (VEGF) drugs are the mainstay of therapy for diabetic macular edema (DME), substantially improving visual acuity for many diabetics worldwide, and proving effec...

Detailed Description

This is a prospective interventional study to evaluate the effect of repeated intravitreal injections of Anti-VEGF on macular perfusion in diabetic patients using optical coherence tomography angiogra...

Eligibility Criteria

Inclusion

  • Patients ≥ 18 years old
  • Type 1 or 2 diabetes mellitus
  • Decreased BCVA due to diabetic macular edema
  • Center involvement by the edema on spectral domain optical coherence tomography (SD OCT)
  • Any stage of diabetic retinopathy

Exclusion

  • Ocular conditions that may affect macular perfusion (e.g. retinal vascular diseases, uveitis, vasculitis etc.)
  • History of vitreoretinal surgeries (excluding intravitreal injections)
  • Any previous treatment for diabetic macular edema
  • Presence of epiretinal membrane involving the macula or vitreomacular traction
  • Media opacity preventing good image quality
  • Uncontrolled glaucoma
  • Thromboembolic events within 6 months

Key Trial Info

Start Date :

October 23 2017

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 24 2018

Estimated Enrollment :

31 Patients enrolled

Trial Details

Trial ID

NCT03246152

Start Date

October 23 2017

End Date

December 24 2018

Last Update

January 30 2020

Active Locations (1)

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Cairo University Faculty of Medicine

Cairo, Egypt