Status:
UNKNOWN
Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.
Lead Sponsor:
George Papanicolaou Hospital
Collaborating Sponsors:
Papanikolaou Evaggelos
Naidecki Robert
Conditions:
Stress Reaction
Opioid Use
Eligibility:
FEMALE
18-32 years
Brief Summary
Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (O...
Detailed Description
The main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via O...
Eligibility Criteria
Inclusion
- American Physical Status I-III, BMI\<30,
Exclusion
- Heart failure
- hepatic failure, hepatitis,
- drug abuse
- receiving b blockers
- receiving b agonists (even bronchodilators)
Key Trial Info
Start Date :
April 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 10 2018
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03248076
Start Date
April 1 2017
End Date
October 10 2018
Last Update
December 14 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Section of Anatomy, Aristotle University of Thessaloniki
Thessaloniki, Greece, 54124