Status:
TERMINATED
Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates
Lead Sponsor:
Stanford University
Collaborating Sponsors:
Siemens Medical Solutions
Conditions:
Coronary Artery Disease
Computed Tomography
Eligibility:
All Genders
21+ years
Brief Summary
Patients with chronic kidney disease (CKD) before kidney transplantation require that obstructive coronary artery disease (CAD) is excluded, as cardiovascular complications are the leading cause of mo...
Detailed Description
Transplantation is the therapy of choice for most patients with stage 5 chronic kidney disease (CKD) and end stage renal disease (ESRD). Kidney transplantation improves quality of life and overall sur...
Eligibility Criteria
Inclusion
- Candidates for kidney transplantation on dialysis without any residual kidney function AND referred to invasive coronary angiography for cardiac evaluation
- Referral to invasive coronary angiography is based on algorithm used at the Transplant Readiness Assessment Clinic (TRAC) at Stanford:
- A. Diabetic Candidates older than 45 years.
- B. Diabetic Candidates under 45 years old and any one of the following criteria is present:
- a) 25 year History of Diabetes
- b) 5 year Smoking History
- c) Abnormal EKG (ST-T wave changes)
Exclusion
- Hemodynamically and clinically unstable condition (angina at rest, malignant arrhythmias)
- Known ischemic heart disease (prior, documented myocardial infarction, prior stenting or coronary artery bypass graft surgery)
- BMI\>30 kg/m2, or weight \>120 kg.
- Atrial fibrillation or other arrhythmia, \>6 ectopic beats per minute
- Known or suspected allergy to iodinated contrast medium
- Pregnancy cannot be excluded
Key Trial Info
Start Date :
August 28 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 24 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03248674
Start Date
August 28 2017
End Date
January 24 2020
Last Update
January 6 2022
Active Locations (1)
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1
Stanford Healthcare
Stanford, California, United States, 94305