Status:
COMPLETED
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Lead Sponsor:
Amsterdam UMC, location VUmc
Collaborating Sponsors:
Niercentrum aan de Amstel, Amstelveen, Netherlands
B.Braun Avitum AG
Conditions:
End Stage Renal Disease (ESRD)
Hemodialysis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dia...
Detailed Description
Despite the use of high permeable dialyzers, which combine diffusive with convective clearance, the clinical outcome of hemodialysis (HD) patients remains poor. In post-dilution online hemodiafiltrati...
Eligibility Criteria
Inclusion
- treatment with HD or HDF 3 x per week during at least 4 hours for at least 2 months
- ability to understand study procedures
- willingness to provide informed consent
- single pool Kt/V urea (spKt/Vurea) ≥ 1.2
- achievement of blood flow of ≥360 ml/min and/or convection volume of \>23 Liter per treatment during the run-in phase
Exclusion
- \- current age \< 18 years
- severe incompliance to dialysis procedure and accompanying prescriptions, especially frequency and duration of dialysis treatment
- life expectancy \< 3 months
- participation in another clinical intervention trial
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03249532
Start Date
June 1 2018
End Date
February 15 2021
Last Update
November 30 2021
Active Locations (3)
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1
St Antonius Ziekenhuis
Nieuwegein, Utrecht, Netherlands, 3435 CM
2
Niercentrum aan de Amstel
Amstelveen, Netherlands, 1186 AM
3
VUmc
Amsterdam, Netherlands