Status:
RECRUITING
Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University
Conditions:
Glioblastoma
WHO Grade II Glioma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This phase II trial studies how well intensity-modulated stereotactic radiation therapy works in treating patients with grade II-IV glioma. Stereotactic radiosurgery is a specialized radiation therapy...
Detailed Description
PRIMARY OBJECTIVES: I. To determine the effect of intensity-modulated (IM)-stereotactic radiotherapy (SRT) on the incidence of wound infection (requiring oral/intravenous \[IV\] antibiotics or surger...
Eligibility Criteria
Inclusion
- Patients must have histologically confirmed low or high grade glioma (grade II-IV)
- Karnofsky performance status (KPS) \>= 60
- Patients must have recovered from the effects of surgery; there must be a minimum of 21 days from the day of surgery to the day of protocol treatment
- Estimated survival \>= 3 months
- Labs considered acceptable per standard of care
- Patient must sign a study specific informed consent form
- Radiation treatment must begin \>= 3 weeks and =\< 8 weeks after surgery
Exclusion
- Prior history of scalp radiation or intolerance to standard course of radiation treatment
- Co-morbidities that would influence wound healing including diabetes (insulin dependent) or smoking (current ongoing use)
- Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
- Karnofsky performance status (KPS) \< 60
- Patient can't have magnetic resonance imaging (MRI) scan
- Active collagen vascular disease
Key Trial Info
Start Date :
July 17 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT03251027
Start Date
July 17 2017
End Date
December 31 2025
Last Update
May 18 2025
Active Locations (1)
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1
Sidney Kimmel Cancer Center at Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107