Status:
COMPLETED
Neural Effects of Cognitive-behaviour Therapy in Panic Disorder
Lead Sponsor:
University of Oxford
Conditions:
Panic Disorder
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Exposure-based cognitive-behaviour therapy (CBT) for anxiety disorders is an effective intervention, but the brain mechanisms driving recovery are largely unknown. In this experimental medicine study,...
Detailed Description
PURPOSE The primary purpose is to enhance our understanding of the mechanisms essential in effective treatment of panic disorder. METHODS Design: The present study has a between-subjects design, incl...
Eligibility Criteria
Inclusion
- Aged 18-70
- Sufficiently fluent in English to understand the task and instructions
- PDSS score of at least 6
- At least two full panic attacks or limited symptoms attacks last 4 weeks
Exclusion
- CNS-acting medication (antidepressants within last 6 months, benzodiazepine last 3 days)
- Current or past history of alcohol/ drug abuse
- Serious medical conditions (e.g., epilepsy, heart or respiratory problems)
- Done the task before
- Waiting group: under current psychotherapeutic treatment
- Pregnancy
- Contraindications to MRI e.g. pacemaker, mechanical heart valve, hip replacement, metal implants
- Severe claustrophobia that limits ability to participate in fMRI scanning
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT03251235
Start Date
January 1 2011
End Date
February 1 2016
Last Update
August 16 2017
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